Twenty years of chronic prostatitis is treated with sensitive antibiotics or alpha blockers depending on whether it is inflammatory or non-inflammatory. Chronic bacterial prostatitis and inflammatory chronic prostatitis should be treated with adequate amounts of sensitive antibiotics. Compound sulfamethoxazole and quinolones have strong penetration to prostate vesicles and can be used for treatment. Antibiotics are not recommended for treatment of non-inflammatory chronic prostatitis, which can be treated with alpha-blockers, such as tamsulosin and doxazosin. Compound sulfamethoxazole drugs block folic acid metabolism, megaloblastic anemia is prohibited, severe liver and kidney function impairment is prohibited. Quinolones drug medication may not have benign reactions as convulsions, dizziness, numbness, polyneuritis, hepatic and renal impairment, etc., and is contraindicated in allergy. Tamsulosin adverse reactions are disorientation, loss of consciousness, drop in blood pressure, dizziness, nausea and vomiting, etc., and is contraindicated in hypersensitivity. Doxazosin is contraindicated in recent myocardial infarction, gastrointestinal obstruction, and hypersensitivity.