Physiologic and pathologic causes should be considered for nausea in the epigastrium. Physiological causes include early pregnancy reaction, overeating, eating stimulating food, etc. Pathological causes include pharyngitis, reflux esophagitis, gastritis, hepatitis and other diseases. 1. Physiological causes: such as early pregnancy reaction in women of childbearing age; such as eating too much can lead to increased gastric digestive burden; eating chili peppers, mustard and other stimulating foods can stimulate gastrointestinal spasms, which can cause nausea and unpleasant symptoms in the upper abdomen. 2. Pathological causes: such as pharyngitis can also have sore throat, pharyngeal itching and other symptoms; such as reflux esophagitis can also have acid reflux, retrosternal pain and other symptoms; such as gastritis can also have acid reflux, stomach pain and other symptoms; such as hepatitis can also have a loss of appetite, yellowing of the skin and other symptoms. For patients with nausea in the epigastric region, it is recommended to go to the hospital in a timely manner to clarify the specific causes and actively treat them.