It is the blackheads that can be squeezed out, not the hair follicles, which cannot be squeezed out. “Blackhead follicles are acne with a large number of keratin plugs, which contain a large number of microorganisms, shedding of hair root sheath cells, sebum, and microbial metabolites, etc. The accumulation of these substances will cause sebum to be unable to secrete normally, and the expansion around the follicle will cause pressure on the follicle wall, which will easily lead to the formation of blackheads and pimples. A large number of microorganisms and their metabolites within the hair follicle, together with the soluble factors they release, will penetrate into the hair follicle wall, inducing a series of inflammatory reactions, forming inflammatory papules locally, or even pustules, nodules, and cysts. Blackhead acne is recommended to be cleared under aseptic operation, otherwise it may aggravate the inflammatory reaction of the hair follicle. This is because if the force is not uniform, resulting in penetration of keratinous components into the dermis, and at the same time the local disinfection is not complete, it can cause a strong inflammatory reaction; if the blackheads acne is located in the danger triangle of the face, the unregulated operation may cause intracranial infection. It is recommended that patients with long blackheads and acne, go to the hospital skin consultation, by the doctor operation to clean out, in order to prevent the occurrence of infection.