Toothache medication needs to be targeted in order to be effective, if it is pulpitis, apical periodontitis pain medication is generally not very useful, the need for root canal treatment, if it is trigeminal neuralgia need to take carbamazepine. 1. Pulpitis, periapical inflammation: toothache may be caused by pulpitis, clinical manifestations of night pain, hot and cold stimulation of severe pain, the general medicine does not play a big role in the effect, the need for root canal treatment to solve the pain. 2. Trigeminal neuralgia: toothache may also be the manifestation of trigeminal neuralgia, the pain often has trigger points, unable to locate the pain site, easy to mistake for endodontic attack, after diagnosis, generally need to take carbamazepine treatment, or consider local physical therapy or surgery. 3. Periodontitis: Periodontal treatment is needed, such as ultrasonic scaling to remove tartar and plaque. However, if there is an abscess, you can take amoxicillin, metronidazole and other antibacterial drugs. Toothache is recommended to the hospital to check the cause of the targeted treatment, the use of drugs need to follow the doctor’s instructions.