Urinary tract infections are usually not oral levofloxacin and amoxicillin at the same time, preferred levofloxacin and other quinolones. 1. The medication for urinary tract infections is generally used for antibiotics that are sensitive to the causative organisms. Before the absence of pathogenetic results, drugs effective against gram-negative bacilli are generally preferred, especially for the first urinary tract infection. Levofloxacin and amoxicillin both have strong antibacterial activity against gram-negative bacilli, and only one of them needs to be taken, preferring quinolones such as levofloxacin. 2. Adverse effects of levofloxacin include nausea, vomiting diarrhea and abdominal pain, etc. It is contraindicated for those who are allergic to quinolones, pregnant and lactating women, and patients under 18 years of age. 3. Amoxicillin adverse reactions include nausea, vomiting, diarrhea and rash, etc., for penicillin allergy is prohibited, for other – lactam agents (such as cephalosporins, carbapenems, monocyclic – lactams) have serious rapid hypersensitivity reactions (such as allergic reactions) is prohibited. All of the above drugs have certain risks, the patient should be under the guidance of a specialist physician to use the drug, do not self-medication.