Urethral opening blisters, it is recommended to go to the hospital for examination, clear etiology after symptomatic treatment. First, if the examination confirms the presence of herpes virus infection, it is recommended to apply topical acyclovir ointment 2-3 times a day for 1 week, and oral antiviral drugs, such as acyclovir capsules 400mg 3-4 times a day for 1 week. Second, if caused by excessive local friction, such as excessive masturbation or physical stimulation, it is recommended to stop the relevant stimulation, the general blisters for about 2-3 days, can gradually subside. For patients who do not recede, you can apply local topical moist burn ointment or a little erythromycin ointment 3 times a day. Third, if there is a bacterial, fungal and other infections, it is recommended to use potassium permanganate solution or sodium bicarbonate solution for local cleaning, after cleaning the bacterial infection topical application of Bactrim ointment a little, 3 times a day. If the diagnosis is caused by fungal infection, then apply a little miconazole ointment 3 times a day for 1 week.