Metformin extended-release tablets generally do not harm the liver. Metformin extended-release tablets are absorbed into the blood circulation through the gastrointestinal tract after taking the drug, and almost do not bind with plasma albumin, do not undergo hepatic metabolism, and achieve the effect of lowering blood glucose by directly acting on the liver and muscle, reducing hepatic glycogen isomerization and increasing the muscle glucose uptake and utilization, therefore, Metformin does not generally hurt the liver. Common adverse reactions to metformin include gastrointestinal reactions such as diarrhea, nausea, vomiting, and dyspepsia, while the rest include headache, dyspnea, rash, and flu syndrome.The drug is contraindicated in people with type 2 diabetes with ketoacidosis, hepatic and renal insufficiency, heart failure, acute myocardial infarction, and people who have an allergic reaction to the product. The drug is a prescription drug and needs to be used under medical supervision.