Ibuprofen cannot be taken after the expiration date, because the efficacy of expired drugs cannot be guaranteed, and side effects may occur because of the deterioration of the drug components, and more seriously, it may cause drug poisoning. Ibuprofen’s expiration date is generally two years, in the safe expiration date of the drug, ibuprofen has antipyretic, analgesic, anti-inflammatory clinical effect, can effectively relieve fever, migraine and other symptoms. Very few patients taking ibuprofen within the expiration date will have some side effects, such as nausea, vomiting, abdominal pain, diarrhea, constipation, heartburn or mild dyspepsia, gastrointestinal ulcers and bleeding, elevated aminotransferases, headache, dizziness, ringing in the ears, blurred vision, nervousness, lethargy, edema of the lower extremities, or sudden increase in body weight and other phenomena. Ibuprofen is contraindicated for those who are allergic to other non-steroidal anti-inflammatory drugs; contraindicated for pregnant and lactating women; contraindicated for asthma patients who are allergic to aspirin. If you accidentally take expired ibuprofen, then you should pay attention to their own condition whether changes, if you feel sick after taking expired ibuprofen, you must go to the hospital as soon as possible, under the guidance of the doctor to carry out emergency treatment, to avoid the expansion of the harm.