HPV refers to human papillomavirus, vaginal opening feel a rough thing may be infected with human papillomavirus caused by local lesions, but also may be the hymen or genital herpes and so on. 1. Human papillomavirus: when a woman is infected with human papillomavirus and has not been treated and eliminated for a long time, the low-risk type of human papillomavirus will cause warts to develop on the vulva and the vaginal opening or the cervix, manifesting itself as a roughness to the touch on the vaginal opening. It may also be accompanied by localized itching sensation, foreign body sensation and other symptoms. 2. Hymen: As the hymen itself is close to the vaginal opening, when it is ruptured and incomplete due to various factors, it will also appear as a rough thing to touch at the vaginal opening. At this time, most of the patients will not experience discomfort. 3. Genital herpes: mainly caused by women infected with the herpes simplex virus, localized clusters of small blisters will appear, manifested in the vaginal opening to feel a rough thing. At the same time there will be localized ulceration, pain and other discomfort. When a woman feels a rough thing on her vagina, it is recommended to go to the hospital in time to rule out abnormalities, and if necessary, follow the doctor’s instructions in time to standardize the treatment, to avoid delaying the condition.