The etiology of difficult upper gastric cardiac fossa includes gastrointestinal diseases such as gastric ulcer, cardiovascular diseases such as myocardial ischemia, liver and gallbladder diseases such as cholecystitis, etc. Medication such as omeprazole, nitroglycerin, etc., and surgical treatment can be given according to the etiology. The details are as follows: 1. Gastrointestinal diseases: if there is difficulty in the upper part of the stomach at the heart of the fossa after eating cold, spicy and other stimulating foods, gastrointestinal diseases are mostly considered, and acid-suppressing drugs such as omeprazole enteric-coated capsules and gastric mucosal protectants such as bismuth potassium citrate can be given to treat the disease. 2. Cardiovascular disease: there are often myocardial ischemia, hypoxia, the onset of the upper part of the stomach at the fossa vaguely uncomfortable, in addition to chest tightness, breathlessness, pain and so on. Nitroglycerin, fast-acting heart pills can be taken, and immediately go to the hospital. 3. Hepatobiliary diseases: chronic cholecystitis patients can appear early in the upper stomach at the heart of the blockage, uncomfortable and other symptoms, clinical often be taken orally dehydrocholic acid tablets, etc. for treatment. If the inflammation recurs, surgery is needed. There may also be other reasons for the vague discomfort in the upper part of the stomach, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.