Ankylosing spondylitis patients should follow the principle of individualization to develop a stable drug treatment program, commonly used drugs are various types of antirheumatic drugs such as sulfasalazine, glucocorticosteroids such as prednisone and non-steroidal anti-inflammatory drugs such as diclofenac. 1. Anti-rheumatic drugs: anti-rheumatic drugs are broadly divided into biosynthetic anti-rheumatic drugs and traditional synthetic anti-rheumatic drugs. Biosynthetic anti-rheumatic drugs include etanercept, adalimumab, etc., which can inhibit bone destruction and alleviate symptoms; traditional synthetic anti-rheumatic drugs include salicylazosulfapyridine, methotrexate, leflunomide, etc., which can improve patients’ symptoms and reduce activity indicators. 2. Glucocorticosteroids: there are many kinds of glucocorticosteroids, including dexamethasone, prednisone, etc., which are not considered to be used in general, and are used for localized medication when the patient has inflammation of skeletal muscles. 3. Non-steroidal anti-inflammatory drugs: Ibuprofen, diclofenac, indomethacin and other non-steroidal anti-inflammatory drugs can play a better role in relieving the common symptoms of ankylosing spondylitis such as low back pain, morning stiffness, joint pain and swelling, but the use of drugs should be careful to exclude the contraindications of the drug. Ankylosing spondylitis patients treatment program should be developed by a professional physician according to the patient’s specific condition, and the above drugs need to be used under the guidance of a physician, it is recommended that ankylosing spondylitis patients to the rheumatology and immunology department of the regular hospital to consult, do not use their own medication.