Glomerulosclerosis half of IgA nephropathy refers to the pathological characteristics of glomerulopathy, during the onset of glomerular capillary collaterals produced sclerotic changes, after the onset of the disease need to give the patient general treatment, medication and other ways. 1. General treatment: after the onset of the disease, we need to actively carry out nutritional maintenance and supportive therapy, with a light diet, pay attention to rest, avoid staying up all night, labor and so on. 2. Drug therapy: drugs are half of the essential treatment measures for IgA nephropathy glomerulosclerosis, and should be combined with the degree of sclerosis of the patient targeted drug therapy. Valsartan, Benadryl and other drugs can be used to control blood pressure, atorvastatin calcium tablets to control blood lipids and insulin to control blood glucose, but also the use of drugs such as xanthosine capsules to actively reduce urinary proteins; in addition to cyclophosphamide tablets, leflunomide tablets and other drugs can be taken to slow down the progression of the disease, and then to achieve the effect of decongestion to reduce the patient’s body edema and urinary frequency and other manifestations. The above drugs should be used according to the doctor’s instructions.The treatment of IgA nephropathy glomerulosclerosis half of the treatment should be carried out quickly, but should follow the doctor’s guidance to choose the targeted treatment measures, do not self-medication.