Monkeypox is an infectious disease caused by the monkeypox virus; it can lead to fever, rash and other adverse symptoms, and in severe cases it can lead to death; clinically, it mainly adopts symptomatic supportive treatment to alleviate the clinical symptoms. Causes: Monkeypox is caused by monkeypox virus infection, it is a zoonosis, infectious, can be transmitted through the respiratory tract, gastrointestinal tract, contact transmission. Symptoms: Monkeypox is relatively acute, with early symptoms including fever, headache, sore throat, back pain, muscle pain, etc.; the rash will appear after 1~3 days of fever and develop rapidly into herpes, forming small pustules, accompanied by enlarged lymph nodes in most of the patients, and may be infected as a complication. Treatment: At present, there is no medicine and method to treat monkeypox, clinically, the main symptomatic supportive treatment, such as itching symptoms can be used potassium permanganate solution, boric acid solution to stop itching; severe symptoms may be used according to the situation of the doctors may use a broad-spectrum antiviral drugs, such as cidofovir. Usually should strengthen the prevention, avoid contact with monkeypox patients; if similar symptoms, should promptly seek medical treatment, in order to achieve early diagnosis, early isolation, early treatment.