Whether urinary protein 1+ is uncomfortable or not depends mainly on the cause of urinary protein. If it is caused by physiological factors such as fever, strenuous exercise, etc., urinary protein can be relieved after resting and usually the body will not feel uncomfortable. If it is caused by glomerulonephritis, urinary tract infection and other pathological factors, edema, frequent urination, urinary urgency and other discomforts may occur. 1. Physiological factors: large amount of food containing high protein, strenuous exercise, fever and other factors may lead to increased protein content in urine. The patient’s kidneys do not have organic lesions, no special treatment is needed, and the urine protein can turn negative by itself after resting, and usually the body will not feel uncomfortable. 2. Pathologic factors: (1) Glomerulonephritis: it may affect the filtration function of kidney, and protein molecules enter into urine, which may lead to increased protein content in urine, at this time, the patient may have many discomforts, mainly manifested as swelling, hematuria, high blood pressure, etc.; some of the patients may be accompanied by fatigue, generalized aches and pains and other symptoms. (2) Urinary tract infection: such as cystitis or pyelonephritis, after the aggravation of the infection, it may lead to the appearance of protein in the urine, which may be accompanied by symptoms such as frequent urination, urgency, pain, etc. Some patients may have fever, generalized body aches, nausea and vomiting. If the patient found that the urine protein 1 +, it is recommended to go to the regular hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.