The cause of scleroderma is still unclear, and may be related to genetics, immune factors, infections, chemical substances and other factors. 1. Genetic factors: It is currently believed that scleroderma is associated with HLA-II genes and may be caused by heredity. 2. Immune factors: It is currently believed that scleroderma is related to the involvement of a variety of immune cells and inflammatory factors such as B lymphocytes and T lymphocytes in the immune system. 3. Infectious factors: The recurrence of various chronic infections in the body, such as human cytomegalovirus and EBV, may trigger scleroderma. 4. Chemical substances: Scleroderma may be induced when the organism is exposed to chemical substances such as silica dust, polyvinyl chloride, formaldehyde, etc. for a long time. When suffering from scleroderma, it is recommended to consult a doctor in time and carry out standardized treatment under the guidance of a doctor.