Highly differentiated squamous cell tongue cancer may recur after surgery, but it is impossible to make a generalization due to the different conditions of individual patients. Tongue cancer is a kind of malignant tumor that occurs in the tongue, and its etiology has not been clearly defined, which may be related to poor oral hygiene, malnutrition, smoking, drinking, and long-term stimulation by foreign bodies. Patients still have the chance of recurrence after surgery for highly differentiated squamous cell tongue cancer. Therefore, patients with highly differentiated squamous cell tongue cancer after surgery should follow the doctor’s instructions to have regular checkups so as to know the recovery of the disease in time. Once recurrence occurs, treatment measures should be taken in time, which can be combined with radiotherapy and chemotherapy. Patients should pay attention to oral care after surgery for highly differentiated squamous cell tongue cancer, and can use saline or mouthwash to clean the mouth and keep oral hygiene clean. If the body is allowed, patients can exercise properly to enhance the immunity of the body. At the same time, it is necessary to quit smoking and drinking, and not to chew betel nut, so as to reduce external stimulation.