Thick and hard foot skin is common in chapped eczema, scaly keratosis pilaris, palmoplantar keratosis and other diseases; patients need to combine the condition, under the guidance of the doctor to choose the appropriate treatment program. 1. Cracked eczema: If the skin of the feet has limited erythema, hypertrophy, flaking, etc., you can consider cracked eczema. Patients need to get rid of allergens, pay attention to foot moisturizing and warmth, etc.; can follow the doctor’s instructions to choose glucocorticosteroids, calcium-modulated phosphatase inhibitors, urea ointment and other topical medications; or oral antihistamines (cetirizine, etc.), antibiotics (combined with bacterial infections), and so on. 2. Scaly keratinized foot manicure: the skin of the feet is thick and hard, accompanied by blisters, flaking and itching, etc. Fungal infection of the feet can be considered. The treatment of this disease is mainly based on topical medication (e.g. salicylic acid and other exfoliators, miconazole antifungal medication), and oral antifungal medication (itraconazole, etc.) is required for serious cases. 3. Palmoplantar keratosis: If there are roughness of palmoplantar skin and thickened plaques on the feet, palmoplantar keratosis can be considered. Patients can take oral vitamin A acid drugs, but also local topical exfoliators (salicylic acid ointment, etc.), vitamin A acid drugs, glucocorticoid drugs (to reduce the inflammatory response). In addition, dry skin or the elderly long-term use of strong irritating toiletries, do not pay attention to moisturizing will make the skin easy to dry and thickening; foot skin if there is a chronic inflammation and external stimulation, recurrent and other influences, can also appear foot skin thickening, hardening. It is recommended that patients go to a regular hospital, under the guidance of a professional doctor, to clarify the cause of the disease and choose the appropriate treatment plan.