High creatinine generally suggests that there may be kidney disease, which may appear water electrolyte metabolism disorders, cardiovascular system, respiratory system, gastrointestinal system, hematologic complications and other systemic symptoms, it is recommended to identify the causes in a timely manner, symptomatic treatment. 1. Water electrolyte metabolism disorder: metabolic acidosis, sodium retention, potassium metabolism disorder, calcium and phosphorus metabolism disorder, magnesium metabolism disorder. 2. Cardiovascular system manifestations: hypertension and left ventricular hypertrophy, heart failure, pericardial lesions, vascular calcification and atherosclerosis. 3. Respiratory system symptoms: shortness of breath can occur in fluid overload or acidosis, and severe acidosis can lead to deep and long breath. Excessive body fluids and cardiac insufficiency can cause pulmonary edema or pleural effusion. 4. Gastrointestinal symptoms: mainly manifested as lack of appetite, nausea, vomiting and so on. 5. Hematological system manifestations: mainly renal anemia, tendency to appear and thrombosis tendency. If the creatinine level reaches the uremia stage, neuromuscular system symptoms such as fatigue, insomnia, memory loss, and in severe cases, indifference, convulsions, hallucinations, coma, and mental abnormality, etc.; endocrine dysfunction such as secondary hyperparathyroidism, etc., may also occur. If patients find that the blood creatinine is elevated, it is recommended that they go to a regular hospital in time, improve the examination to clarify the cause of the disease, and then give targeted treatment or therapy under the guidance of the doctor.