Frequent colic in the middle of the night may be related to irregular diet, indigestion, gastrointestinal spasm, chronic enteritis, etc., and should be treated according to the cause. 1. Irregular diet: If you tend to eat too much greasy and spicy food at night, it will easily lead to colic in the middle of the night. Generally, colic symptoms can be relieved through dietary adjustments. 2. Indigestion: If you eat indigestible food, it may lead to gastrointestinal contractions and spasms, resulting in colic symptoms. Therefore, you can eat foods that help digestion, such as apples, yogurt, etc.; or take oral probiotics, such as Bifidobacterium bifidum, etc.; or take digestive drugs, such as Domperidone, etc., under the guidance of a doctor. 3. Spasm of the gastrointestinal tract: If you get cold at night, it can lead to spasm of the gastrointestinal tract, causing colic. At this time, hot water bag or massage can be used to relieve; if the pain symptoms are more serious, you can take pivacurium bromide and other drugs under the guidance of the doctor to treat. 4. Chronic enteritis: frequent colic, may also be accompanied by fever, diarrhea and other symptoms, should seek medical attention in a timely manner, considering the chronic irritation of the intestinal tract, under the guidance of the doctor to take anti-inflammatory drugs treatment. As you can see, frequent colic in the middle of the night, we should first look for the relevant causes, and then carry out targeted treatment.