Yunke, technetium methylene diphosphonate injection, has anti-inflammatory, analgesic, immunomodulatory and bone-breaking and repairing effects in the treatment of ankylosing spondylitis, and has been shown to be effective in improving morning stiffness, limitation of joint function, and lowering the rate of blood sedimentation. Its main ingredient is technetium 99, which is a radioactive substance and belongs to isotope therapy. It is a new type of drug for the treatment of ankylosing spondylitis, however, it is often combined with immunosuppressive drugs in clinical studies of ankylosing spondylitis treatment. Ankylosing spondylitis is a type of arthritis that has long-term symptoms of inflammation in the joints of the spine, and its treatment includes exercise, medications, and surgery. The following medications are also required depending on the condition, including disease-relieving anti-rheumatic drugs such as non-steroidal anti-inflammatory drugs like ibuprofen, corticosteroids, and salazosulfapyridine, as well as biologics like infliximab. If the diagnosis of ankylosing spondylitis is confirmed, it is necessary to combine the characteristics of the disease and choose the appropriate treatment plan under the guidance of the doctor.