A hypodense shadow in the liver is a sign of a lesion in the liver, including benign and malignant lesions. Hypodense shadows in the liver is an imaging term for lesions in the liver, including benign and malignant lesions of the liver. Its normal liver density is relatively uniform, the occurrence of malignant lesions may be a malignant tumor of the liver, the patient will have nausea, vomiting, pain in the liver area, itching and other symptoms, then need to consult a doctor in time for diagnosis and treatment. Benign lesions mostly refer to cystic foci and benign tumors of the liver, including liver trauma, infection, fatty liver, etc. If the patient’s hepatic cysts are asymptomatic, they need to be reviewed regularly and do not require treatment; if they are accompanied by symptoms (anorexia greasy, pain, swelling, vomiting, etc.) and the diameter is larger than 5 cm, they require further treatment. The presence of liver hypodense shadow need to seek medical attention to identify the cause of the disease.