The curative factors of pancreatic cancer are complex, both endogenous (genetic factors) and exogenous (environmental, dietary and other factors). Research literature published in 2010 in the world’s leading journal Nature states that there is a gradual evolution from normal pancreatic ductal epithelial cells to cancer. It takes 9 years from genetic mutation to the formation of a true tumor cell, 8 years from the development of a tumor cell into a mass of cells with the ability to metastasize, and nearly 2 years less from the discovery of a tumor to the death caused by the tumor. Therefore, adverse factors that cause cellular malignancy should be avoided as much as possible to prevent the occurrence of pancreatic cancer. Smoking: It is the only recognized high risk factor for the development of pancreatic cancer. A large number of foreign prospective studies and case-control studies have shown that the risk ratio of pancreatic cancer patients who smoke to non-smokers who die is 1.6-3.1:1; experimental studies have proved that carcinogenic substances in tobacco can cause cancerous changes in the epithelium of the pancreatic duct. Unhealthy diet: The World Cancer Research Fund and the American Institute for Cancer Research have summarized the relationship between diet and pancreatic cancer. It is believed that foods rich in red meat (pork, beef, lamb), high fat and high energy may increase the risk of pancreatic cancer, while the incidence of pancreatic cancer can be prevented by consuming a diet rich in vegetables and fruits by 33%-50%. Genetic factors: The incidence of pancreatic cancer is 3-13 times higher in those with a family history than in those without. It is reported that the risk of pancreatic cancer in one family member is 4 times higher than that of the general population, rising to 12 times for two people and up to 40 times for three people. Professor Ni found that mother-daughter, father-son, sibling, and grandchild pancreatic cancer families have encountered many cases, and they are strengthening their research. Chronic lesions of the pancreas: Recurrent chronic pancreatitis, pancreatic duct stones or stone pancreatitis have a tendency to become cancerous and can be considered as a pre-cancerous lesion. Attention should be paid to the treatment of the primary disease closely followed by the onset of the disease also associated with the body itself, such as having chronic pancreatic lesions, oral diseases, etc. Diabetes: Studies have found that diabetic patients are two times more likely to develop pancreatic cancer than the normal population. The incidence of diabetes in patients with pancreatic cancer is also almost twice as high as in the normal population. Therefore, patients with no family history of diabetes must be carefully examined to exclude pancreatic cancer when they are suddenly found to have diabetes. Benign pancreatic tumors: Like other organs, there are many benign tumors in the pancreas. For example, plasmacytoma or mucinous cystadenoma, solid pseudopapillary tumor, intraductal mucinous papilloma, etc., which can also be malignant to pancreatic cancer, especially mucinous papilloma and intraductal mucinous papilloma. Oral diseases: Some studies have shown that dental caries and other oral inflammatory lesions also increase the incidence of pancreatic cancer. Others: Those with familial adenomatous polyposis, those with benign lesions undergoing major distal gastrectomy, biliary tract disease, surgical removal of the gallbladder, and those positive for Helicobacter pylori also increase the risk of pancreatic cancer.