Closed-cell acne that hurts to touch can be treated with topical medications, as well as through acne removal procedures and fruit acid peels. Closed pimples are mild acne and usually have no accompanying symptoms. The presence of localized pain may be due to a secondary inflammatory response. The treatment should be to keep the face clean, and can be treated with topical isotretinoin gel, adapalene gel, and benzoyl peroxide gel as prescribed by the doctor. Additionally, acne can be removed using an acne squeezer or a combination of peel treatments with fruit acid can be applied to remove acne. If you are diagnosed with closed acne, follow your doctor’s instructions for treatment.