There is no study on the specific blood concentration of Dapoxetine affected by smoking, but the blood concentration of Dapoxetine will be reduced to less than 5% of the peak concentration after 24 hours of dosing, so for safety reasons, smoking is recommended after 24 hours. Smoking affects the efficacy of dapoxetine and also affects your health. Long-term smoking can cause lung and cardiovascular diseases, so smoking is not recommended. Dapoxetine can inhibit the reabsorption of 5-hydroxytryptamine, thus inhibiting the function of neurotransmitters, making the ejaculatory reflex delayed, to achieve the role of the treatment of premature ejaculation. This product can lead to the development of nausea, fatigue, insomnia, headache, dizziness, diarrhea and other adverse reactions after the use of the drug. This product is contraindicated in patients with class II-IV heart failure, atrioventricular block, significant myocardial ischemia, valvular lesions, and moderate to severe liver injury. It should also be noted that this product is not to be taken at the same time with alcohol. Patients need to use the drug under the guidance of a specialized physician and strictly follow the doctor’s instructions.