Taking sacubitril valsartan sodium tablets may cause some damage to kidney function, but the severity of the damage generally varies from person to person. Sacubitril valsartan sodium tablets contain sacubitril and valsartan; sacubitril is a brain curcuminoid peptidase inhibitor, and valsartan is an angiotensin receptor antagonist; this drug can alleviate the symptoms of patients with heart failure and reduce the risk of cardiovascular death in patients, and it can also be used to treat essential hypertension. The main adverse effects of this drug include angioedema, hypotension, renal impairment, hyperkalemia, etc.; because this drug can inhibit the renin-angiotensin-aldosterone system in the body, it may lead to varying degrees of renal impairment, and it may also cause elevations in hyperkalemia, blood urea, and blood creatinine, which can lead to further impairment of renal function. Sacubitril valsartan sodium tablets are contraindicated in people who are allergic to the components of the drug; it is forbidden to combine with angiotensin-converting enzyme inhibitor drugs; it is forbidden to use it for drug-related angioedema; it is forbidden to use it for hepatic toxicity impairment and for pregnant women. Precautions: the use of this drug need to regularly monitor renal function, the emergence of renal impairment need to consult a doctor in a timely manner, after a comprehensive assessment to adjust the dose of the drug, do not adjust the dose to avoid delays in the condition. It is recommended that patients take Sacubitril valsartan sodium tablets under the guidance of a doctor to regulate, so as to avoid adverse consequences.