Lamivudine and entecavir, it does not matter which one is better, both belong to the nucleotide class of antiviral drugs, it is recommended to go to the hospital for standardized treatment. Lamivudine and entecavir are both drugs belonging to the treatment of hepatitis B, with the effect of inhibiting the replication of hepatitis B virus. At present, entecavir or tenofovir or propofol tenofovir is generally preferred for antiviral treatment of chronic hepatitis B. Lamivudine is not preferred due to its high rate of resistance. The most common adverse reactions to entecavir are headache, fatigue, dizziness, diarrhea, nausea, rash, elevated blood creatinine, loose stools, abnormal platelet count, hemoglobin count, and white blood cell count. It is contraindicated in people who are allergic to entecavir. Lamivudine adverse reactions: the most common are malaise, respiratory tract infection, headache, abdominal discomfort, nausea, vomiting and diarrhea, gastritis, hyperglycemia, anemia, weakness and splenomegaly, etc. It is contraindicated in those who are allergic to lamivudine. Lamivudine and entecavir should not be applied on their own, it is recommended to go to the hospital and be guided by a specialist.