The causes of toothache include pulpitis, dental caries, trigeminal neuralgia, etc., which need to be treated with medication and surgery. 1. For pulpitis, oral ibuprofen and other antipyretic and analgesic drugs can be taken as prescribed by the doctor; medication can only provide temporary pain relief, and then thorough root canal treatment can be carried out for a complete cure. 2. For caries, fluoride drugs such as 8% stannous fluoride solution, eugenol and other drugs can be used as prescribed by the doctor; when the caries cavity is large, it needs to be filled and repaired after removing the decay. 3. For the trigeminal neuralgia caused by, can be prescribed oral carbamazepine and other anti-epileptic drugs, vitamin B1 and other vitamins; drug treatment is ineffective, can be considered trigeminal nerve microvascular decompression surgery. It is recommended that people with toothache go to a regular hospital in a timely manner to clarify the cause of the disease, standardized treatment under the guidance of the doctor, so as not to delay the condition, the use of drugs need to comply with medical advice.