The ingredient of Polivir is clopidogrel, clopidogrel and aspirin can’t be assessed which one is better, it depends on which drug is more suitable for the patient. Clopidogrel and aspirin mainly inhibit platelet aggregation, mainly used in the treatment of arterial thrombotic diseases, the main clinical indications for coronary heart disease, cerebral thrombosis and so on. Clinical efficacy of the two drugs can not be directly assessed, can not say which drug is better, both drugs have a good anti-platelet effect, depending on which drug is more suitable for patients to take. Aspirin mainly through the inhibition of cyclooxygenase to play the role of anti-vascular, clopidogrel’s main role is to inhibit the ADP receptor, the two mechanisms of action are different. The main adverse reactions of aspirin are dyspnea, nausea, vomiting, abdominal pain, gastrointestinal bleeding, skin and mucous membrane bleeding, cerebral hemorrhage, etc. It is forbidden to use it in patients who are allergic to the components of the drug, aspirin-related asthma, active hemorrhage, active ulcers, hemophilia. Adverse reactions of clopidogrel include stomach pain, gastric distension, diarrhea, skin mucous membrane bleeding, gastrointestinal bleeding, cerebral hemorrhage, etc. It is contraindicated in patients with allergy to drug components, active bleeding. Clinical oral aspirin and clopidogrel in the treatment of ischemic cardiovascular and cerebrovascular diseases should be applied under the guidance of a physician, and the choice of drugs suitable for the patient.