Irbesartan taken twice a day may lower blood pressure compared to before, and may even have consequences such as hypotension, tachycardia or bradycardia. Clinically, Irbesartan belongs to the angiotensin II receptor inhibitors, which can inhibit vasoconstriction as well as the release of aldosterone, thus producing the effect of lowering blood pressure. It is mainly used in the treatment of essential hypertension, as well as hypertension in combination with type 2 diabetes and renal disease. Usually Irbesartan is taken once a day, if it is taken twice a day, it may cause overdose of the drug, which may result in discomfort such as hypotension, tachycardia or bradycardia. In addition, Irbesartan may cause adverse reactions such as postural vertigo, postural hypotension, and skeletal muscle pain after taking it. Irbesartan should be used with caution, allergy to the components of this drug, women in the 4th to 9th month of pregnancy, breastfeeding women are prohibited from using it. During the period of taking the drug, you need to pay attention to monitoring kidney function, liver function and blood pressure. If you need to take Irbesartan for antihypertensive treatment, it is recommended to follow the doctor’s instructions and not to change the dosage of the drug on your own.