Glandular soft tissue sarcoma is a malignant tumor of soft tissue of unknown origin with glandular or organoid arrangement of cells, first reported by Christopherson in 1952. The disease occurs in adolescent females and is most common in the deep muscles or fascia of the extremities. The tumor grows slowly and is painless in the early stages. It can metastasize to lung, bone, brain, subcutaneous and other sites. Treatment is based on surgical resection and regular follow-up after surgery. Adenoid soft tissue sarcoma is a malignant soft tissue tumor of unknown origin. Clinical manifestations Adenoid soft tissue sarcoma usually occurs in adolescent females, mostly located in the deep muscles or fascia of the extremities, and a few can be seen in the abdominal wall, paranal area, tongue, retroperitoneum and back of the neck. The tumor grows slowly and is painless in the early stage, and is often found by chance. The large ones are 6-10 cm in diameter. Tumors do not grow rapidly, but blood circulation is abundant and pulsation can be palpated in superficial cases, including tumors of 1 cm in diameter that metastasize to the subcutaneous area, and pulsation is also obvious. Some patients may have extensive metastasis, mainly to lung, bone, brain, subcutaneous and other sites, and a few have lymphatic metastasis. For metastasis to bone, well-defined osteolytic destruction along the long axis of the bone without periosteal reaction, which resembles the characteristics of some bone metastatic carcinomas. The final diagnosis depends on tissue biopsy. Diagnosis Adenoid soft tissue sarcoma is difficult to diagnose based on history, clinical manifestations, and examination, and the final diagnosis requires tissue biopsy. The disease should be differentiated from adenoid rhabdomyosarcoma and adenocarcinoma. Treatment In principle, wide excision of the tumor should be performed for adenoid soft tissue sarcoma, but the recurrence rate is as high as 70%. The tumor is insensitive to chemotherapy and radiotherapy, and the efficacy is not certain, so the patient must have regular follow-up after surgery. With comprehensive examination, early detection and early surgery, patients can survive and work for a long time.