Hyperdense shadow is a common descriptive term used in imaging. A small nodular hyperdense shadow of the humeral head is considered to be a condition such as tendon calcification, osteophyte, or bone tumor. Due to repeated pulling of the subscapularis, latissimus dorsi, and vastus lateralis muscles attached to the humeral tuberosity, aseptic inflammation occurs at the local ligament stops, which may cause local soft tissue calcification. When the shoulder joint is internally retracted and rotated, pain usually occurs. Degenerative hyperplasia of the shoulder joint causes degenerative hyperplasia in the area of the humeral tuberosity and limitation of joint movement, which can usually be clearly diagnosed by taking X-ray films. Bone tumors cause bone destruction and calcification of bone, which can be clearly diagnosed by performing enhanced CT. Humerus tuberosity high density shadow with shoulder joint pain, need to receive further examination under the guidance of the doctor, clear diagnosis, targeted treatment.