Severe hypoproteinemia can be treated using methods such as general treatment and medication. 1. General treatment: the treatment of primary disease should be strengthened. With the improvement of primary diseases, many patients’ hypoproteinemia can be gradually normalized. Critically ill patients can be given albumin, which can effectively increase serum albumin. 2. Drug therapy: there are some differences between individuals, drugs are recommended to be used under the guidance of a doctor. (1) Recombinant human growth hormone can promote protein synthesis in critically ill patients, which can effectively improve protein metabolism, and can also improve the inflammatory response of critically ill patients. (2) Branched-chain amino acids are the key regulators of various nutritional metabolisms, and have certain therapeutic effects on hepatic encephalopathy and hypoproteinemia combined with cirrhotic patients. (3) Lamivudine can significantly improve liver function and increase serum albumin level in cirrhotic patients. (4) Albumin can also be infused symptomatically. Patients with severe hypoproteinemia are advised to go to the hospital in time and adopt appropriate methods of treatment under the guidance of doctors.