Secondary respiratory failure is clinically called type II respiratory failure, and bronchoscopy can be done for patients with chronic obstructive pulmonary disease combined with type II respiratory failure who are in stable condition. Contraindications to bronchoscopy include extremely debilitated general status, psychiatric disorders, cardiac insufficiency, and severe hypertension, while those who have acute purulent inflammation of the respiratory tract with high fever, acute asthma attacks, and those who are hemoptysis can be examined after their condition has resolved. For patients with chronic obstructive pulmonary disease combined with type II respiratory failure, timely treatment is needed to keep the airway open, low-flow oxygen, and at the same time to correct hypoxemia, hypercapnia; in addition to the use of bronchodilators, antibiotics, glucocorticosteroids, as well as replenishment of electrolytes and fluids and other treatment measures, so that the patient’s condition is stabilized before the bronchoscopy examination. Remind patients: patients with chronic obstructive pulmonary disease combined with type II respiratory failure, it is recommended to immediately seek medical treatment, under the doctor’s comprehensive physical assessment to determine whether it is possible to do bronchoscopy.