Diclofenac sodium suppositories and cotrimoxazole tablets can be used together, but they should be used together under the supervision of a doctor. Diclofenac sodium suppository is a kind of anti-inflammatory and analgesic drug, belonging to non-steroidal anti-inflammatory drugs, which is suitable for osteoarthritis, ankylosing spondylitis, rheumatoid arthritis, postoperative pain, and fever caused by various reasons. Compound aminophenol alkylamine tablets are a class of compound preparations, clinically used to relieve symptoms such as cough, nasal congestion, runny nose, sneezing, and fatigue caused by colds. Although the two medicines can be taken together, some people using diclofenac sodium suppositories may cause gastrointestinal discomfort, and compound aminoglutethimide tablets may sometimes cause nausea, lack of appetite and other symptoms. Taking the two drugs together may produce some gastrointestinal reactions, so people who have gastrointestinal symptoms try to avoid taking the two drugs at the same time. If symptoms occur, seek medical attention to avoid adverse effects.