Acanthosis nigricans is a rare skin disease, which can be treated by different methods according to the benign or malignant nature of the disease, such as general treatment, medication, surgery and so on. 1. General treatment: for benign acanthosis nigricans patients, firstly, we need to remove the cause of the disease; for patients with primary diseases, we need to actively treat the primary diseases, such as obese patients need to reduce their weight appropriately; patients with endocrine disorders need to correct them in time; for acanthosis nigricans caused by medicines, we can stop taking the relevant medicines in time. 2. Drugs: For benign acanthosis nigricans patients, after removing the causative factors, local topical keratolytic agents such as carbotriol, salicylic acid and other drugs can be used to promote the stripping of the local stratum corneum to play a therapeutic role. 3. Surgery: For patients with malignant acanthosis nigricans, there may be malignant tumors, which need to be treated by surgical excision according to the specific conditions of patients. As each patient’s condition is different, the treatment method is also different, and reasonable treatment should be carried out under the guidance of professional doctors. The medication should be used according to the doctor’s prescription.