The differentiation between acanthosis nigricans and pseudoacanthosis nigricans includes the scope of the disease and the treatment. 1. Disease scope: acanthosis nigricans is a rare skin disease, including benign acanthosis nigricans, obesity acanthosis nigricans, symptomatic acanthosis nigricans, unilateral acanthosis nigricans, limb acanthosis nigricans and so on, pseudo acanthosis nigricans belongs to one kind of acanthosis nigricans, which is the most common acanthosis nigricans in clinic, and is related with obesity, and is also known as obesity acanthosis nigricans. 2. Treatment: The treatment of acanthosis nigricans mainly adopts medication and surgery, benign acanthosis nigricans mainly adopts medication, and malignant acanthosis nigricans can be treated by surgery. Pseudoacanthosis nigricans is a benign form of acanthosis nigricans, which usually subsides naturally after weight control or can be cured with medication. Patients need to go to the hospital and follow the doctor’s instructions to complete the relevant examinations to identify the cause of the disease and carry out treatment.