Patients with acanthosis nigricans usually have no conscious symptoms, and only have skin pigmentation in the early stage, and it is recommended to consult a doctor in time. Acanthosis nigricans is a rare skin disease, in addition to localized lesions at the lesion, the patient has no conscious symptoms, lesions occur in the softer parts of the skin, commonly found in the breasts, armpits, the side of the neck, umbilical fossa, groin, genitalia, near the anus, etc., but also in the eyelids, the back of the hands, elbow and other parts of the body. Early lesions may only have skin pigmentation, with the development of lesions, the affected skin color gradually deepened to light gray, light brown or dark brown, the surface of the lesions may also have many small papillae raised like velvet, soft to the touch. If the patient has the above symptoms and suspects the existence of acanthosis nigricans, he/she should consult a doctor in time, make a clear diagnosis of the disease under the doctor’s guidance, and follow the doctor’s instructions to carry out the corresponding treatment.