Entecavir has been taken for 8 years and the virus still can’t come down, considering the development of drug resistance or poor patient compliance, you need to go to the hospital to be judged by a professional doctor to adjust the medication. Entecavir is mainly used for the treatment of chronic adult hepatitis B. It can inhibit the replication of hepatitis B virus. Entecavir can inhibit the replication of hepatitis B virus and inhibit the synthesis of the positive chain of HBV DNA, which is very effective for the hepatitis B virus in the active replication period. However, under the current medical conditions, it can not completely eradicate the hepatitis B virus, and it can be converted to negative, that is, the major triple positive is converted to minor triple positive. The patient has been taking it for 8 years and it has not come down, it may be the development of drug resistance. In addition, it is also necessary to find the reasons on the part of the patient, whether the patient takes it regularly every day as required, whether there is a self-suspension or omission of taking it, and so on. Entecavir has been taken for 8 years and still can not come down, it is recommended to go to the hospital to find out the cause, and then follow the doctor’s instructions for appropriate treatment.