Oral H. pylori is also known as oral Hp. Oral Hp can be removed by supragingival cleansing, subgingival scraping, or periodontal flap surgery, and gastric H. pylori can be removed by quadruple therapy as appropriate. Oral Hp is usually detected from saliva, and dental plaque is a reservoir for H. pylori, which can be detected in periodontal pockets. If Hp infection is detected in the breath test, it is actually an Hp infection in the stomach; if it is an oral Hp infection, it is recommended that a further breath test be performed to have determined if there is a gastric Hp infection. Generally for patients with Hp infection in the stomach, Hp removal can be carried out according to the actual situation, and at present the main use of quadruple therapy; for patients with Hp infection in the mouth, supragingival cleaning can be carried out in the stomatology department in order to remove plaque; for patients with periodontitis with periodontal pockets, subgingival scraping or periodontal flap surgery can be carried out. It is recommended that patients with H. pylori in the oral cavity should seek prompt medical attention and standardize treatment under the guidance of a physician.