Male inguinal lymph node swelling may be due to inflammation, malignant tumor metastasis, connective tissue disease and other causes, the specific medication needs to be selected according to the cause of the disease. 1. Inflammation: male inguinal lymph node swelling is due to inflammation, soft tissue infection and other causes, according to the pathogen, choose the appropriate drug treatment. If the bacterial infection is caused by penicillin v potassium tablets, amoxicillin capsule, roxithromycin capsule, cefuroxime capsule and other antibiotic drugs; such as viral infections, you can take acyclovir, ribavirin and other antiviral drugs; if it is due to the skin fungal infections and other causes, the infected area can be used externally with ketoconazole ointment and other antifungal drugs treatment. 2. Tumor metastasis: If malignant tumor metastasis causes male inguinal lymph node enlargement, you need to go to the hospital in time to improve the examination, clear diagnosis, and then follow the doctor’s instructions to be the appropriate anti-tumor treatment. 3. Connective tissue disease: such as systemic lupus erythematosus, nodular disease, etc., improve the examination, after a clear diagnosis can be glucocorticoids (such as prednisolone), immunomodulatory drugs (such as interferon) and other treatments as prescribed by the doctor. When men find that the inguinal lymph nodes are enlarged, it is recommended to go to the hospital in a timely manner to conduct relevant examinations, to clarify the cause of the disease, and to carry out targeted treatment as soon as possible.