Azithromycin and memantine (also known as minocycline hydrochloride) does not have which one is more effective, should be individualized according to the cause of the patient’s disease. 1. Azithromycin is a macrolide antibiotic. It is used to treat acute pharyngitis and tonsillitis, sinusitis, otitis media, respiratory infections caused by Mycoplasma pneumoniae. Adverse reactions include dyspepsia, headache, drowsiness, bronchospasm, rash, and pruritus. It is contraindicated for those who are allergic to azithromycin, or other macrolides or ketolactones, or those who have cholestatic jaundice and hepatic insufficiency from previous use of azithromycin. 2. Minocycline hydrochloride, belongs to tetracycline antibiotics. It can be used for urethritis, superficial purulent infection, otitis media, syphilis, dysentery, enteritis, peritonitis and so on. Adverse reactions include pancytopenia, hearing impairment, diarrhea, nausea, dyspepsia, dysphagia, headache, dullness of sensation, and sensory abnormalities. It is contraindicated for those who are allergic to any tetracyclines or this product. As the above two drugs belong to different kinds of antibiotics, the mechanism of action and indications are not exactly the same. Doctors should choose the right drug for the patient according to the patient’s specific disease, based on comprehensive consideration of drug sensitivity, indications, contraindications, etc. to avoid the occurrence of adverse reactions.