Toothache in pregnant women is caused by wisdom tooth pericoronitis, periodontal disease, dental caries or endodontics, and can be palliatively treated due to special circumstances that make conventional treatment inappropriate. If a pregnant woman has a toothache during pregnancy, the risk of treatment is relatively low if the pregnancy is in the fourth to sixth month, but palliative care is required after consultation and evaluation by an obstetrician/gynecologist; i.e., the main focus is on relieving pain and inflammation, and conventional treatment can be carried out after the delivery of the baby. During this period, treatments include rinsing and medication for peri-crown and periodontal diseases of wisdom teeth; temporary observation for mild caries symptoms, and in contrast, protective filling with less irritating temporary filling materials, and permanent filling after delivery; and temporary pain relief and anti-inflammation for endodontic diseases, which can be preceded by opening and draining of the pulp of the tooth, and then complete root canal treatment after delivery. Pregnant women should pay attention to oral care to ensure that the oral cavity clean, through frequent rinsing, diligent brushing and other daily care to prevent tooth pain.