Vulvar leukoplakia may become malignant. Vulvar leukoplakia is also known as vulvar leukoplakia, vulvar dystrophy, etc. Nowadays, it is more often called vulvar hypopigmented diseases, etc. Among the common vulvar hypopigmented diseases, vulvar chronic simple moss has a lower chance of malignant transformation, and vulvar sclerosing moss has the possibility of malignant transformation in about 2% to 5% of cases, which can be biopsied at the chafing, ulceration, and spasm, to make a clear pathologic diagnosis. Vulvar chronic simple moss has a low chance of malignant lesions, and most of them are treated with medication and physical therapy. When atypical hyperplasia or the possibility of malignancy occurs, surgical treatment can be used, with the possibility of recurrence. Vulvar sclerosing moss is effective in most cases through medication, but most of them improve the symptoms and cannot be cured, and there is a possibility of malignant lesions, mainly non-human papilloma related squamous carcinoma, which requires long-term follow-up. Patients with vulvar leukoplakia are advised to consult a doctor in a timely manner and be given appropriate examination and treatment under the guidance of a specialized doctor.