Some acute hepatitis B can turn negative naturally, but chronic hepatitis B will not turn negative naturally. Whether or not hepatitis B can naturally turn negative mainly refers to whether or not the surface antigen of hepatitis B naturally turns from positive to negative, which can be categorized into two clinical situations. 1. Acute hepatitis B: The vast majority of acute viral hepatitis B does not require antiviral treatment and has a good prognosis. The majority of patients with acute hepatitis B can be cured on their own, and the surface antigen of hepatitis B will become negative, and a small number of patients can progress to chronic hepatitis B. 2. Chronic hepatitis B: patients’ hepatitis B surface antigen will not turn negative naturally, all need to be treated. For the treatment of chronic hepatitis B is mainly antiviral therapy, antiviral therapy generally choose oral drugs, such as entecavir, tenofovir, lamivudine and so on. Chronic viral hepatitis B is less likely to turn negative, only a very small number of chronic hepatitis B patients to achieve surface antigen negative. At present, there is no effective drug that can effectively make hepatitis B negative, chronic hepatitis B patients need to actively cooperate with the doctor’s treatment.