There is a certain possibility that a large two-positive test result will turn into a large three-positive test result, but it is very unlikely. The big two positive refers to the hepatitis B virus surface antigen, e antigen positive, while the big three positive refers to the hepatitis B virus surface antigen, e antigen and core antibody positive, the test results of big two positive patients if the virus replication is active, have certain symptoms of liver damage, there is a certain possibility to change into big three positive. Both patients with triple positive and double positive should undergo regular liver function and abdominal ultrasound examinations, and if liver function is impaired, they should undergo antiviral treatment and hepatoprotective treatment to avoid cirrhosis and hepatocellular carcinoma, and should pay attention to their diets in their daily lives. If there is a big two yang, should consult a doctor in time.