The extent of the sequelae of total removal of the spleen is not clear clinically, after the spleen is completely removed, it may cause the white blood cells to rise, the patient’s platelets will also rise within a short period of time, the coagulation of blood will increase, the red blood cells rise and other sequelae. The complete removal of the spleen may also lead to gastrointestinal and respiratory infections, which may cause damage to the immune system, and most importantly, to the blood system of the human organism. As an important immune organ and a major lymphatic organ in the human body, after the spleen is removed, the red blood cells, hemoglobin and white blood cells in the blood routine will be abnormal. Moreover, the spleen has the function of destroying platelets, which are involved in blood coagulation, and if this function is destroyed, the number of platelets will increase, which will lead to an increase in the coagulability of blood and the formation of blood clots easily. Therefore, after the spleen has been completely removed, you must insist on going to the hospital regularly for routine checkups, keeping an eye on the changes in platelets and observing the condition of the blood system at all times. If the body develops the phenomenon of hypercoagulable blood clots, anticoagulant treatment must be carried out in time, and attention should also be paid to increasing the nutrition in the later stage.