Acne refers to acne in medicine. Staying up all night and getting acne is due to the fact that staying up all night for a long period of time makes sebaceous glands produce more, which leads to the growth and aggravation of acne. The way to regulate acne includes adjusting work and rest, topical medication (tazarotene cream, etc.), and internal medication (isotretinoin, etc.). 1. Adjusting work and rest: For patients who have acne after staying up all night, they should pay attention to adjusting their work and rest routines to avoid sleeping too late and having a serious lack of rest time. Generally, after actively regulating sleep, acne will be relieved. In the near future, you should also adjust your state of mind to avoid excessive stress and worry. 2. Topical medications: Tazarotene cream, adapalene gel, vinpocetine cream and other medications can be used to control the symptoms as prescribed by the doctor, and topical benzoyl peroxide, fusidic acid cream and other medications can also be applied to regulate the treatment. 3. Internal medication: If there is no special contraindication, patients can take oral isotretinoin and other medications. It is recommended that acne sufferers actively seek medical attention and treatment, and the above medications should be used in accordance with the doctor’s instructions, so as not to aggravate the condition.