Ankylosing spondylitis is well treated with biological agents, which are a landmark in the treatment of ankylosing spondylitis and have epochal significance. In the past, traditional drugs, such as salazosulfapyridine, were mainly used for treatment, which was very slow to take effect, and patients needed to take the drug every day for a long time, with great side effects, and not every patient was effective, and patients often needed to take it for three months before they could see results. Biological agents have the advantages of fast onset, good efficacy and little side effects, etc. They have been used in foreign countries for more than 20 years and in China for more than 10 years, and have accumulated a large number of cases with good efficacy. The long-term use of no side effects or side effects is very small, can slow down the progress of the disease, to prevent patients hunchback, so ankylosing spondylitis playing biological agents is very good.