Ankylosing spondylitis, also known as seronegative spondyloarthropathy, is one type of spondyloarthritis in a group. Ankylosing spondylitis most commonly presents with injury to the spine, neck, shoulders, low back, back, and even some hips and ankles. The most common manifestations are pain, swelling and stiffness of the joints. In the early stages of the disease, ankylosing spondylitis mainly presents with inflammation of the spinal joints and surrounding bones. However, as the disease progresses, the joints of the spine may fuse, which is the long-term development of ankylosing spondylitis. Ankylosing spondylitis is mainly associated with genetics, and genes play a significant role in the development of ankylosing spondylitis. Many patients with ankylosing spondylitis have ankylosing spondylitis as part of their immediate family. So ankylosing spondylitis is a group of diseases that are closely linked to genetic factors and can cause swelling, pain and stiffness in the neck, shoulders, back and even some hip and knee joints and even ankle joints. This group of diseases can sometimes damage the body’s internal organs, such as the heart and eyes, and even intestinal damage can occur in some patients. So ankylosing spondylitis is a group of autoimmune diseases that primarily hurt the joints in the spine, but may also hurt internal organs.