The use of biologics for the treatment of ankylosing spondylitis is an important milestone in the history of the treatment of long straight spondylitis. For two decades biologics have saved countless patients with ankylosing spondylitis from suffering from musculoskeletal back pain, delayed the progression of the disease, and prevented spinal dystonia. There are many biologics currently used in clinical treatment of ankylosing spondylitis, such as tumor necrosis factor antagonists, with TNF-α antagonists, interleukin-6 antagonists, interleukin-1 inhibitors, etc. It is recommended by experts and has been clinically proven in large scale abroad and at home that the treatment of ankylosing spondylitis with good efficacy and few side effects is the tumor necrosis factor antagonist, also called TNF-α antagonist, which is easy to use and can be injected subcutaneously once a week. It is good and fast-acting, and can suppress the inflammation quickly. The tumor necrosis factor antagonist is recommended when the blood sedimentation C-reactive protein returns to normal and the patient’s back pain disappears. The specific drug to be used is decided by experts and doctors.